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Peer-Reviewed Publication
Nat Aging2025;5(7):1195-1206.July 1, 2025Journal Article

Skin health and biological aging.

David Furman1,2,3,4, Johan Auwerx5,6, Anne-Laure Bulteau7, George Church5,8,9, Virginie Couturaud10, Laure Crabbe7, Kelvin J A Davies5,11,12, Anabelle Decottignies5,13, Vadim N Gladyshev5,14, Brian K Kennedy5,15,16, Nicola Neretti5,17, Carine Nizard7, Karl Pays7, Daisy Robinton5,18, Vittorio Sebastiano5,19, Rachel E B Watson20, Meng C Wang5,21, Knut Woltjen5,22
1Stanford 1000 Immunomes Project, Stanford School of Medicine, Stanford, CA, USA. dfurman@buckinstitute.org.
2Buck Bioinformatics and Data Science Platform, Buck Institute for Research on Aging, Novato, CA, USA. dfurman@buckinstitute.org.
3IIMT, Universidad Austral, Consejo Nacional de Investigaciones Científicas y Técnicas, Pilar, Argentina. dfurman@buckinstitute.org.
4Reverse Aging Board, Parfums Christian Dior, Neuilly-sur-Seine, France. dfurman@buckinstitute.org.
5Reverse Aging Board, Parfums Christian Dior, Neuilly-sur-Seine, France.
6Laboratory of Integrative Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
7LVMH Recherche, Saint Jean de Braye, France.
8Wyss Institute for Biologically Inspired Engineering, Boston, MA, USA.
9Department of Genetics, Harvard Medical School, Boston, MA, USA.
10Department of Scientific Communication, Parfum Christian Dior, Neuilly sur Seine, France.
11Leonard Davis School of Gerontology; and Division of Molecular & Computational Biology, Department of Biological Sciences of the College of Letters, Arts & Sciences, University of Southern California, Los Angeles, CA, USA.
12Department of Biochemistry & Molecular Medicine of the Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
13Université Catholique de Louvain, de Duve Institute, Louvain-la-Neuve, Belgium.
14Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
15Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
16Centre for Healthy Longevity, National University Health System, Singapore, Singapore.
17Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, USA.
18Oviva Therapeutics, Brooklyn, NY, USA.
19Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA, USA.
20A*STAR Skin Research Labs (A*SRL), Agency for Science, Technology and Research (A*STAR), National Skin Centre & Skin Research Institute of Singapore (SRIS), Singapore, Republic of Singapore.
21HHMI Janelia Research Campus, Ashburn, VA, USA.
22Kyoto University, Yoshidahonmachi, Sakyo Ward, Kyoto, Japan.
PubMed DOI

Abstract

Accumulating evidence indicates that biological aging can be accelerated by environmental exposures, collectively called the 'exposome'. The skin, as the largest and most exposed organ, can be viewed as a 'window' for the deep exploration of the exposome and its effects on systemic aging. The complex interplay across hallmarks of aging in the skin and systemic biological aging suggests that physio…

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