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Peer-Reviewed Publication
Clin Nutr2025;519-17.August 1, 2025Journal Article

Automated three-dimensional body composition analysis identifies visceral adipose tissue radiodensity as a predictor of mortality and recurrence in colorectal cancer.

Dinh Van Chi Mai1, Ioanna Drami2, Edward T Pring3, Laura Gould4, Jason Rai3, George Malietzis5, Phillip Lung3, Vincent Chow6, Karteek Popuri7, Mirza F Beg6, Thanos Athanasiou8, John T Jenkins3, 9
1St Mark's Hospital and Academic Institute, St Mark's The National Bowel Hospital, Central Middlesex Hospital, Acton Ln, NW10 7NS, London, United Kingdom; Department of Surgery and Cancer, Imperial College London, United Kingdom. Electronic address: dinh@doctors.org.uk.
2St Mark's Hospital and Academic Institute, St Mark's The National Bowel Hospital, Central Middlesex Hospital, Acton Ln, NW10 7NS, London, United Kingdom; Department of Digestion, and Reproduction, Imperial College London, United Kingdom.
3St Mark's Hospital and Academic Institute, St Mark's The National Bowel Hospital, Central Middlesex Hospital, Acton Ln, NW10 7NS, London, United Kingdom; Department of Surgery and Cancer, Imperial College London, United Kingdom.
4St Mark's Hospital and Academic Institute, St Mark's The National Bowel Hospital, Central Middlesex Hospital, Acton Ln, NW10 7NS, London, United Kingdom; School of Cancer Sciences, College of Veterinary & Life Sciences, University of Glasgow, United Kingdom.
5St Mark's Hospital and Academic Institute, St Mark's The National Bowel Hospital, Central Middlesex Hospital, Acton Ln, NW10 7NS, London, United Kingdom; Department of Surgery and Cancer, Imperial College London, United Kingdom; Mediterranean Hospital, Limassol, Cyprus.
6School of Engineering Science, Simon Fraser University, Vancouver, British Columbia, Canada; Voronoi Health Analytics Incorporated, Vancouver, British Columbia, Canada.
7Voronoi Health Analytics Incorporated, Vancouver, British Columbia, Canada; Dept of Computer Science, Memorial University of Newfoundland, Newfoundland and Labrador, Canada.
8Department of Surgery and Cancer, Imperial College London, United Kingdom.
9St Mark's Hospital and Academic Institute, St Mark's The National Bowel Hospital, Central Middlesex Hospital, Acton Ln, NW10 7NS, London, United Kingdom.
PubMed DOI

Abstract

BACKGROUND: Artificial intelligence enables automated three-dimensional (3D) volumetric body composition (BC) analysis from computed tomography (CT), opposed to single third lumbar vertebra (L3) slices alone. This study aimed to identify relationships between 3D BC and postoperative colorectal cancer (CRC) outcomes utilising Voronoi Health Analytics' Data Analysis Facilitation Suite software. MET…

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