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Peer-Reviewed Publication
Eur Radiol2025;35(12):8202-8213.December 1, 2025Journal Article

Breast cancer in women after withdrawing from an increased-risk MRI screening program.

Suzanne L van Winkel1, Riccardo Samperna2, Elizabeth A Loehrer2,3, Caroline A Drukker4, Kelly Sessink2, Nico Karssemeijer2,5, Ritse M Mann2,6
1Medical Imaging Department, Radboudumc: Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. suzanne.vanwinkel@radboudumc.nl.
2Medical Imaging Department, Radboudumc: Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
3Department of Clinical Genetics, Erasmus MC: Erasmus University Medical Center, Rotterdam, The Netherlands.
4Department of Surgical Oncology, Netherlands Cancer Institute; Antoni van Leeuwenhoek (NKI), Amsterdam, The Netherlands.
5ScreenPoint Medical BV, Nijmegen, The Netherlands.
6Department of Radiology, Netherlands Cancer Institute; Antoni van Leeuwenhoek (NKI), Amsterdam, The Netherlands.

Abstract

OBJECTIVE: This study evaluates breast cancer (BC) detection in women with ≥ 20% lifetime risk who discontinued annual breast MRI screening surveillance. MATERIALS AND METHODS: This retrospective single screening cohort (2003-2019) study included 3308 women who received at least one breast MRI. After verifying with the Netherlands Comprehensive Cancer Organization (IKNL), a sub-population of wome…

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