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Contemp Clin Trials2025;155107962.August 1, 2025Journal Article

The Grief Navigation Trial: A multi-site pragmatic comparative effectiveness trial of two interventions to support parents after their child's unexpected or traumatic death.

Elaf Agha1, Carolyn Sutter2, Ifeoluwadolapo Ojewuyi3, Emily M Abramsohn3, Megan Andriano4, Christal Bell5, Anna L Calix6, Jamie Lynn Cherry7, Kim Downing1, Tina Flower8, Michelle Halm9, Ashley Hayes2, Marie E Heffernan2, JaShawn Hill10, C Zoe Hoeppner11, Meghan Jacobson1, Jacquelyn Jennings12, Leslie Kula-Leitner1, SuYeon Lee3, Deborah R Major13, Jennifer A Makelarski14, Nancy L Maruyama15, Amy McNicholas1, Steve Newton16, Charlotte Shuber17, Anthony T Vesco18, Stacy Tessler Lindau19, Kelly N Michelson20,
1The HAP Foundation, 18W140 Butterfield RD. Suite 1120, Oakbrook Terrace, IL 60181, United States of America.
2Smith Child Health Catalyst, 303 East Superior Street, Chicago, IL 60611, United States of America; Mary Ann & J. Milburn Smith Child Health Outcomes, Research, and Evaluation Center, United States of America; Stanley Manne Children's Research Institute, 303 East Superior Street, Chicago, IL 60611, United States of America; Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E Chicago Ave, Chicago, IL 60611, United States of America.
3The University of Chicago, 5801 S Ellis Ave, Chicago, IL 60637, United States of America; Department of Obstetrics and Gynecology, University of Chicago, 5801 S Ellis Ave, Chicago, IL 60637, United States of America.
4Willow House, 2231 Lakeside Dr, Bannockburn, IL 60015, United States of America.
5Be Support: Grief Network for Youth & Families, United States of America.
6Gifts From Liam, United States of America.
7Life Without My Child, Evanston, IL, United States of America.
8Path Technologies, 3-4460 Queen Kaahumanu Highway, #138, Kailua-Kona, HI 96740, United States of America.
9Grief Connection Space, LLC., United States of America; Bridgepoint Psychology Center, 5547 N Ravenswood Ave Suite 201, Chicago, IL 60640, United States of America.
10Chicago Survivors, 1010 W 35th St #510, Chicago, IL 60609, United States of America.
11A Community of Love NFP, United States of America.
12Fox Valley Hands of Hope, 200 Whitfield Dr, Geneva, IL 60134, United States of America.
13Loving Outreach to Survivors of Suicide Loss (LOSS) Program, 721 N. LaSalle Street, Chicago, IL 60654, United States of America; Catholic Charities of the Archdiocese of Chicago, 721 N. LaSalle Street, Chicago, IL 60654, United States of America.
14The University of Chicago, 5801 S Ellis Ave, Chicago, IL 60637, United States of America; Tulane University, 6823 St Charles Ave, New Orleans, LA 70118, United States of America.
15Sudden Infant Death Services of Illinois, Inc., 6010 Route 53, Suite A, Lisle, IL 60532, United States of America.
16Lake County Coroner's Office, 26 N Martin Luther King Jr Ave, Waukegan, IL 60085, United States of America.
17Buddy's Place, 5220 East Avenue, Countryside, IL 60525, United States of America.
18Pritzker Department of Psychiatry and Behavioral Health, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E Chicago Ave, Chicago, IL 60611, United States of America; Department of Psychiatry & Behavioral Sciences, Northwestern University Feinberg School of Medicine, 420 E Superior St, Chicago, IL 60611, United States of America.
19The University of Chicago, 5801 S Ellis Ave, Chicago, IL 60637, United States of America; Department of Obstetrics and Gynecology, University of Chicago, 5801 S Ellis Ave, Chicago, IL 60637, United States of America; Department of Medicine - Geriatrics and Palliative Medicine, University of Chicago, 5801 S Ellis Ave, Chicago, IL 60637, United States of America.
20Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E Chicago Ave, Chicago, IL 60611, United States of America; Division of Critical Care Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E Chicago Ave, Chicago, IL 60611, United States of America; Department of Pediatrics, Northwestern University Feinberg School of Medicine, 420 E Superior St, Chicago, IL 60611, United States of America. Electronic address: kmichelson@luriechildrens.org.
PubMed DOI

Abstract

BACKGROUND: In the US, ~60,000 people <25 years old die annually. Forty-five percent of pediatric deaths occur traumatically, and the parents' or caregivers' (hereafter 'parents') sole contact with the healthcare system is often the coroner or medical examiner (ME). Parents experience mental and physical health problems following their child's death. There are no evidence-based interventions for M…

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