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Peer-Reviewed Publication
Alzheimers Dement2025;21(5):e70310.May 1, 2025Journal Article

Predicting progression from MCI to dementia using cortical disarray measurement from diffusion MRI.

Mario Torso1, Pegah Khosropanah1, Steven A Chance1, Gerard R Ridgway1
1Oxford Brain Diagnostics Ltd, Oxford, UK.
PubMed PMC DOI PDF

Abstract

BACKGROUND: This study evaluates the capability of cortical microstructural measures from diffusion magnetic resonance imaging (MRI) to predict progression from mild cognitive impairment (MCI) to dementia, compared to commonly used macrostructural measures. Identification of high-risk individuals can support both clinical practice and trials. METHODS: Structural and diffusion MRI scans of 826 par…

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