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Peer-Reviewed Publication
J Orthop Surg Res2025;20(1):473.May 16, 2025Journal Article

Diagnostic challenges of carpal tunnel syndrome in patients with congenital thenar hypoplasia: a comprehensive review.

Hamed Naghizadeh1, Omid Salkhori1, Shahram Akrami2, Seyyed Saeed Khabiri1, Aidin Arabzadeh3,4
1Joint Reconstruction Research Center, Department of Orthopedics, Tehran University of Medical Sciences, Tehran, Iran.
2Department of Physical Medicine and Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran.
3Joint Reconstruction Research Center, Department of Orthopedics, Tehran University of Medical Sciences, Tehran, Iran. Aidin.medico@gmail.com.
4Department of Orthopedic Surgery, Imam Khomeini Hospital Complex, Tehran University of Medical Science, Keshavarz Boulevard, Tehran, Iran. Aidin.medico@gmail.com.

Abstract

Carpal Tunnel Syndrome (CTS) is the most common entrapment neuropathy, frequently presenting with pain, numbness, and muscle weakness due to median nerve compression. However, diagnosing CTS becomes particularly challenging in patients with Congenital Thenar Hypoplasia (CTH), a rare congenital anomaly characterized by underdeveloped thenar muscles. The overlapping symptoms of CTH and CTS, such as…

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