Peer-Reviewed Publication
Neurology2025;104(10):e213618.May 27, 2025Journal Article
Multiple Sclerosis-Specific Reference Curves for Brain Volumes to Explain Disease Severity.
David Rudolf van Nederpelt1, Lonneke Bos1, Rozemarijn M Mattiesing1, Eva M M Strijbis2, Bastiaan Moraal1, Joost Kuijer1, Jeroen Hoogland3, Henk J M M Mutsaerts1, Bernard Uitdehaag2, Joep Killestein2, Lizette Heine4, Bas Jasperse1, Frederik Barkhof1,5, Menno M Schoonheim6, Hugo Vrenken1
1MS Center Amsterdam, Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, the Netherlands.
2MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, the Netherlands.
3Department of Epidemiology and Data Science, Amsterdam UMC, the Netherlands.
4Quantib B.V., DeepHealth, Rotterdam, the Netherlands.
5UCL London, Institutes of Neurology and Healthcare Engineering, London, United Kingdom; and.
6MS Center Amsterdam, Anatomy and Neurosciences, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, the Netherlands.
Abstract
BACKGROUND AND OBJECTIVES: Brain atrophy is relevant for understanding disease progression and treatment response in people with multiple sclerosis (pwMS). Automatic brain volume-reporting tools often rely on healthy control (HC) reference curves to interpret brain volumes, whereas brain volume loss is different in pwMS. This observational study aimed to develop an MS-specific reference model for…
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