Health AI Central
Peer-Reviewed Publication
Infect Agent Cancer2025;20(1):26.April 18, 2025Journal Article

Cost-benefit analysis of p16INK4a immunocytology and liquid-based cytology triage after primary HPV testing for cervical cancer screening in China.

Dachuang Zhou1,2, Jun Hou3,4,5, Jiayi Xi1,2, Yuan Li1,2, Xinfeng Qu6,7,8, Wenxi Tang9,10, Ruifang Wu11,12,13
1Department of Pharmacoeconomics, School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, Jiangsu, China.
2Center for Pharmacoeconomics and Outcomes Research, China Pharmaceutical University, Nanjing, Jiangsu, China.
3Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
4Institute of Obstetrics and Gynecology, Shenzhen Peking University-Hong Kong University of Science and Technology Medical Center (PKU-HKUST) Medical Center, Shenzhen, China.
5Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases, Shenzhen, China.
6Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, 518036, China. steve1005@icloud.com.
7Institute of Obstetrics and Gynecology, Shenzhen Peking University-Hong Kong University of Science and Technology Medical Center (PKU-HKUST) Medical Center, Shenzhen, China. steve1005@icloud.com.
8Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases, Shenzhen, China. steve1005@icloud.com.
9Department of Pharmacoeconomics, School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, Jiangsu, China. tokammy@cpu.edu.cn.
10Center for Pharmacoeconomics and Outcomes Research, China Pharmaceutical University, Nanjing, Jiangsu, China. tokammy@cpu.edu.cn.
11Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, 518036, China. wurf100@126.com.
12Institute of Obstetrics and Gynecology, Shenzhen Peking University-Hong Kong University of Science and Technology Medical Center (PKU-HKUST) Medical Center, Shenzhen, China. wurf100@126.com.
13Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases, Shenzhen, China. wurf100@126.com.
PubMed PMC DOI PDF

Abstract

BACKGROUND: HPV testing has become the recommended primary screening method for cervical cancer in China. However, referring all HPV-positive patients for colposcopy is not practical. This study monetized clinical performance metrics to evaluate the relative performance of 10 secondary triage strategies compared to referring all patients for colposcopy. METHODS: Using real-world HR-HPV sample dat…

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