Development of a personalized digital biomarker of vaccine-associated reactogenicity using wearable sensors and digital twin technology.

Steven R Steinhubl¹, Jadranka Sekaric², Maged Gendy², Huaijian Guo³, Matthew P Ward⁴, Craig J Goergen⁴, Jennifer L Anderson⁴, Sarwat Amin⁴, Damen Wilson⁴, Eustache Paramithiotis³, Stephan Wegerich²

¹Purdue University, W, Lafayette, IN, USA. ssteinhu@purdue.edu.

²Prolaio Health, Scottsdale, AZ, USA.

³CellCarta, Montreal, QC, Canada.

⁴Purdue University, W, Lafayette, IN, USA.

PubMed PMC DOI PDF

Abstract

BACKGROUND: Effective response to vaccination requires activation of the innate immune system, triggering the synthesis of inflammatory cytokines. The degree of subjective symptoms related to this, referred to as reactogenicity, may predict their eventual immune response. However, the subjective nature of these symptoms is influenced by the nocebo effect, making it difficult to accurately quantify…

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