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Nat Commun2025;16(1):2948.April 8, 2025Journal Article

Molecular subtyping of hypertensive disorders of pregnancy.

Michal A Elovitz1,2, Elaine P S Gee1, Nathaniel Delaney-Busch1, Alison B Moe1, Mitsu Reddy1, Arkady Khodursky1, Johnny La1, Ilma Abbas1, Kay Mekaru1, Hunter Collins1, Farooq Siddiqui1, Rory Nolan1, Rupsa C Boelig3, Daniel G Kiefer4, Pamela M Simmons5, George R Saade6, Antonio Saad7, Ebony B Carter8, Thomas F McElrath1,9, Stephen R Quake10,11,12, Mark A DePristo13, Carrie Haverty1, Manfred Lee1, Eugeni Namsaraev1, Vincenzo Berghella3, Ai-Ris Y Collier14,15, Antonia I Frolova16, Esther Park-Hwang17, Luis D Pacheco18, Elizabeth F Sutton5, Maneesh Jain1, Kara Rood19, William A Grobman19, Joseph R Biggio20, Cynthia Gyamfi-Bannerman21, Arun Jeyabalan22, Morten Rasmussen23
1Mirvie Inc., South San Francisco, CA, USA.
2Nuttall Women's Health, New York, NY, USA.
3Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
4Women's Care Florida, Orlando, FL, USA.
5Woman's Hospital, Baton Rouge, LA, USA.
6Eastern Virginia Medical School, Norfolk, VA, USA.
7Inova Health, Falls Church, VA, USA.
8University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
9Brigham Women's Hospital, Boston, MA, USA.
10Department of Bioengineering, Stanford University, Stanford, CA, USA.
11Chan Zuckerberg Biohub, Stanford, CA, USA.
12Department of Applied Physics, Stanford University, Stanford, CA, USA.
13BigHat Biosciences Inc., San Mateo, CA, USA.
14Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
15Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA.
16Washington University School of Medicine, St. Louis, MO, USA.
17MultiCare Health System, Tacoma, WA, USA.
18Univerity of Texas Medical Branch, Galveston, TX, USA.
19The Ohio State University, Columbus, OH, USA.
20Ochsner Health, New Orleans, LA, USA.
21University of California San Diego, San Diego, CA, USA.
22University of Pittsburgh, Pittsburgh, PA, USA.
23Mirvie Inc., South San Francisco, CA, USA. morten@mirvie.com.
PubMed PMC DOI PDF

Abstract

Hypertensive disorders of pregnancy (HDP), including preeclampsia, affect 1 in 6 pregnancies, are major contributors to maternal morbidity and mortality, yet lack precision medicine strategies. Analyzing transcriptomic data from a prospectively-collected diverse cohort (n = 9102), this study reveals distinct RNA subtypes in maternal blood, reclassifying clinical HDP phenotypes like early/late-onse…

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