Peer-Reviewed Publication
Cerebellum2025;24(3):72.March 25, 2025Journal Article
miR-512-3p as a Potential Biomarker of Poor Outcome in Pediatric Medulloblastoma.
Carolina Alves Pereira Corrêa1, Pablo Shimaoka Chagas1, Mirella Baroni1, Augusto Faria Andrade2, Rosane Gomes de Paula Queiroz3, Veridiana Kiill Suazo3, Gustavo Alencastro Veiga Cruzeiro4, Paola Fernanda Fedatto3, David Santos Marco Antonio5, Silvia Regina Brandalise6, José Andres Yunes6, Rodrigo Alexandre Panepucci7, Carlos Gilberto Carlotti Junior8, Ricardo Santos de Oliveira8, Luciano Neder9, Luiz Gonzaga Tone1,3, Elvis Terci Valera3, Carlos Alberto Scrideli10,11,12
1Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
2Department of Human Genetics, McGill University, Montreal, Canada.
3Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14048-900, Brazil.
4Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
5Seven Bridges Biotech Consulting, São Paulo, Brazil.
6Boldrini Children's Center, Laboratory of Molecular Biology, Campinas, Brazil.
7Hemocentro Foudation, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
8Department of Surgery, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
9Department of Pathology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
10Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil. scrideli@fmrp.usp.br.
11Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14048-900, Brazil. scrideli@fmrp.usp.br.
12National Science and Technology Institute for Children's Cancer Biology and Pediatric Oncology - INCT BioOncoPed, Porto Alegre, Brazil. scrideli@fmrp.usp.br.
Abstract
The tumorigenesis of medulloblastoma (MB), the most frequent malignant brain tumor in children, is not completely known. MicroRNA (miRNA) expression profiles have been associated with human cancers; however, the role played by miRNAs in pediatric MB has been poorly explored. Global miRNA expression in MB and non-neoplastic cerebellum samples was evaluated by microarray assay. Nine miRNAs (miR-31-5…
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