Efficient evaluation of the precision of quantitative chromatographic analysis of soft capsules using a chemometric tool.

Ai Sano¹, Akira Kotani², Hideki Hakamata², Masato Takahashi³

¹TOYO CAPSULE Co., Ltd., 560 Nakazato-higashi-cho, Fujinomiya-shi, Shizuoka, 418-0046, Japan. Electronic address: a8_sano@toyo-cap.co.jp.

²School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.

³TOYO CAPSULE Co., Ltd., 560 Nakazato-higashi-cho, Fujinomiya-shi, Shizuoka, 418-0046, Japan; Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.

PubMed DOI

Abstract

Soft capsules may enhance oral absorption and bioavailability of active substances by appropriately combining them with excipients such as lipids and surfactants. However, these excipients affect the determination of active substances and warrant several considerations for establishing optimal analytical methods. The function of mutual information (FUMI) theory is a chemometric tool that estimates…

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