Health AI Central
Peer-Reviewed Publication
Nutrients2025;17(5)March 6, 2025Journal Article

Precision Medicine in Cardiovascular Disease Prevention: Clinical Validation of Multi-Ancestry Polygenic Risk Scores in a U.S. Cohort.

Małgorzata Ponikowska1,2, Paolo Di Domenico1, Alessandro Bolli1, George Bartholomew Busby1, Emma Perez1,3, Giordano Bottà1
1Allelica Inc., San Francisco, CA 94105, USA.
2Department of Biology and Medical Genetics, Faculty of Medicine, Medical University of Gdansk, 80-210 Gdansk, Poland.
3Brigham and Women's Hospital, Boston, MA 02115, USA.
PubMed PMC DOI PDF

Abstract

BACKGROUND: Polygenic risk score (PRS) quantifies the cumulative effects of common genetic variants across the genome, including both coding and non-coding regions, to predict the risk of developing common diseases. In cardiovascular medicine, PRS enhances risk stratification beyond traditional clinical risk factors, offering a precision medicine approach to coronary artery disease (CAD) preventio…

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