Peer-Reviewed Publication
Ann Diagn Pathol2025;76152462.June 1, 2025Journal Article
Development of a digital algorithm for assessing tumor-stroma ratio, tumor budding and tumor infiltrating lymphocytes in vulvar squamous cell carcinomas.
Louise Baandrup1, Susanne K Kjær2, Óli Jacobsen3, Michael Bzorek3, Thomas Thiilmark Eriksen4, Lise Grupe Larsen3, Anne-Marie Kanstrup Fiehn5
1Department of Pathology, Zealand University Hospital, Denmark; Unit of Virus, Lifestyle and Genes, Danish Cancer Institute, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark. Electronic address: lobaa@cancer.dk.
2Unit of Virus, Lifestyle and Genes, Danish Cancer Institute, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark; Department of Gynecology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
3Department of Pathology, Zealand University Hospital, Denmark.
4Visiopharm A/S, Hoersholm, Denmark.
5Department of Pathology, Zealand University Hospital, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark.
Abstract
Tumor-stroma ratio (TSR), tumor budding (TB), and tumor-infiltrating lymphocytes (TILs) are prognostic markers in some cancers but with unknown significance in vulvar squamous cell carcinoma (VSCC). This pilot study primarily aimed to develop a digital method for evaluating TSR, TB and TILs in VSCC and secondarily to investigate variation in these factors by p16 status. An independent training set…
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