Health AI Central
Peer-Reviewed Publication
J Natl Cancer Inst2025;117(6):1245-1252.June 1, 2025Journal Article

Body composition and checkpoint inhibitor treatment outcomes in advanced melanoma: a multicenter cohort study.

Mark Schuiveling1, Laurens S Ter Maat2, Isabella A J Van Duin1, Rik J Verheijden1,3, Max F Troenokarso1, Pim Moeskops4, Joost J C Verhoeff5, Sjoerd G Elias3, Wouter A C van Amsterdam6, Femke Burgers7, Franchette W P J Van den Berkmortel8, Marye J Boers-Sonderen9, Martijn F Boomsma10, Jan Willem De Groot11, John B A G Haanen7,12,13, Geke A P Hospers14, Djura Piersma15, Gerard Vreugdenhil16, Hans M Westgeest17, Ellen Kapiteijn12, Mariette Labots18, Wouter B Veldhuis4,19, Paul J Van Diest20, Pim A De Jong19, Josien P W Pluim2,21, Tim Leiner4,22, Mitko Veta21, Karijn P M Suijkerbuijk1
1Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
2Image Sciences Institute, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
3Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
4Quantib (currently DeepHealth), Rotterdam, The Netherlands.
5Department of Radiotherapy, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
6Department of Data Science and Biostatistics, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
7Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
8Department of Medical Oncology, Zuyderland Medical Center, Sittard-Geleen, The Netherlands.
9Department of Medical Oncology, Radboudumc, Radboud University, Nijmegen, The Netherlands.
10Department of Radiology, Isala Zwolle, Zwolle, The Netherlands.
11Isala Oncology Center, Isala Zwolle, Zwolle, The Netherlands.
12Department of Medical Oncology, Leiden University Medical Center, Leiden University, Leiden, The Netherlands.
13Melanoma Clinic, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
14Department of Medical Oncology, UMC Groningen, University of Groningen, Groningen, The Netherlands.
15Department of Medical Oncology, Medisch Spectrum Twente, Enschede, The Netherlands.
16Department of Medical Oncology, Maxima Medical Center, Veldhoven, The Netherlands.
17Department of Internal Medicine, Amphia Hospital, Breda, The Netherlands.
18Department of Medical Oncology, UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands.
19Department of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
20Department of Pathology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
21Medical Image Analysis, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
22Department of Radiology, Mayo Clinical, Rochester, MN, United States.
PubMed PMC DOI PDF

Abstract

BACKGROUND: The association of body composition with checkpoint inhibitor outcomes in melanoma is a matter of ongoing debate. In this study, we aim to investigate body mass index (BMI) alongside computed tomography (CT)-derived body composition metrics in the largest cohort to date. METHODS: Patients treated with first-line anti-PD1 ± anti-CTLA4 for advanced melanoma were retrospectively identifi…

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