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Peer-Reviewed Publication
J Med Virol2025;97(2):e70207.February 1, 2025Journal Article

Clinical and Multiorgan Proteomics Characteristics of the Diverse Fatal Phase in Super Elderly Patients With SARS-CoV-2 Infection: A Descriptive Study.

Shuxia Wang1, Jin Sun1,2, Yazhuo Hu3, Wei Zhang4, Bangguo Qin2, Man Li1, Nan Zhang1,2, Shengshu Wang3, Tingyu Zhou5, Miao Liu6, Cong Ma7, Xinli Deng8, Yongyi Bai9, Geping Qu10, Lin Liu10, Hui Shi11, Bo Zhou12, Ke Li12, Bo Yang13, Suxia Li13, Fan Wang9, Jinling Ma9, Lu Zhang9, Yajuan Wang10, Li An10, Wenhui Liu11, Qing Chang11, Ru Zhang11, Xi Yin12, Yang Yang12, Qiangguo Ao14, Qiang Ma14, Shuangtong Yan15, Haili Huang16, Peng Song16, Shu Zhao16, Linggen Gao17, Wenning Lu17, Lining Xu17, Li Lei7, Keyu Wang8, Qing Song18, Zhijian Zhang10, Xiangqun Fang10, Yao He3, Qi Zhang19, Jianjun Jia3, Ping Zhu1
1Department of Geriatrics, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
2Medical School of Chinese PLA, Beijing, China.
3Institute of Geriatrics, The Second Medical Center, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatrics Diseases, Chinese PLA General Hospital, Beijing, China.
4Department of Integrative Therapy, The Second Medical Center, Chinese PLA General Hospital, Beijing, China.
5National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
6Department of Anti-NBC Medicine, Graduate School of Chinese PLA General Hospital, Beijing, China.
7Department of Health Medicine, The Second Medical Center, Chinese PLA General Hospital, Beijing, China.
8Department of Clinical Laboratory, The Second Medical Center, Chinese PLA General Hospital, Beijing, China.
9Department of Cardiology, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
10Department of Respiratory and Critical Care Medicine, The Second Medical Center, Chinese PLA General Hospital, Beijing, China.
11Department of Gastroenterology, The Second Medical Center, Chinese PLA General Hospital, Beijing, China.
12Department of Neurology, The Second Medical Center, Chinese PLA General Hospital, Beijing, China.
13Department of Hematology, The Second Medical Center, Chinese PLA General Hospital, Beijing, China.
14Department of Nephrology, The Second Medical Center, Chinese PLA General Hospital, Beijing, China.
15Department of Endocrinology, The Second Medical Center, Chinese PLA General Hospital, Beijing, China.
16Department of MedicaI Oncology, The Second Medical Center, Chinese PLA General Hospital, Beijing, China.
17Department of General Surgery, The Second Medical Center, Chinese PLA General Hospital, Beijing, China.
18Department of Critical Care Medicine, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
19The Second Medical Center, PLA General Hospital, Beijing, China.
PubMed DOI

Abstract

This study aims to identify the risk factors associated with clinical outcomes and the proteomic changes in organs related to fatal SARS-CoV-2 infection within the super-elderly population. This retrospective analysis included all elderly individuals with COVID-19 admitted to the Second Medical Center of PLA General Hospital from December 2022 to January 2023. The follow-up period ended on March 3…

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