Peer-Reviewed Publication
Invest Ophthalmol Vis Sci2025;66(2):6.February 3, 2025Journal Article
Targeted Microperimetry Grids for Focal Lesions in Intermediate AMD: PINNACLE Study Report 7.
Stefan Futterknecht1,2, Philipp Anders3, Julia Mai4, Sophie Riedl4, Ursula Hall1,2, Chrysoula Gabrani1,2, Kristina Pfau2, Martin J Menten5,6, Daniel Rueckert5,6, A Toby Prevost7, Hrvoje Bogunovic8, Lars G Fritsche9, Ursula Schmidt-Erfurth4, Sobha Sivaprasad10,11, Andrew Lotery12, Hendrik P N Scholl1,13, Maximilian Pfau1,2
1Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.
2Department of Ophthalmology, Universitätsspital Basel, Basel, Switzerland.
3Vista Klinik, Binningen, Switzerland.
4Laboratory for Ophthalmic Image Analysis, Medizinische Universität Wien, Wien, Austria.
5BioMedIA, Department of Computing, Imperial College London, London, United Kingdom.
6Institute for AI and Informatics in Medicine, School of Computation, Information and Technology, School of Medicine and Health, Technical University Munich, München, Germany.
7Nightingale-Saunders Clinical Trials and Epidemiology Unit, King's College London, London, United Kingdom.
8Institute of Artificial Intelligence, Center for Medical Data Science, Medical University of Vienna, Wien, Austria.
9Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, United States.
10National Institute of Health and Care Research Moorfields Biomedical Research Centre Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom.
11Institute of Ophthalmology, University College London, London, United Kingdom.
12University of Southampton Faculty of Medicine, Southampton, United Kingdom.
13Current affiliation: Department of Clinical Pharmacology, Medizinische Universität Wien, Wien, Austria.
Abstract
PURPOSE: The purpose of this study was to evaluate the feasibility and utility of optical coherence tomography (OCT)-based, targeted microperimetry grids in assessing focal lesions in intermediate age-related macular degeneration (iAMD).
METHODS: The multicenter, prospective PINNACLE study enrolled 395 patients with iAMD aged 55 to 90 years across 12 international sites. Participants underwent im…
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