Curcumin-laden hydrogel coating medical device for periprosthetic joint infection prevention and control.

Nina Burduja¹, Nicola F Virzì², Giuseppe Nocito³, Giovanna Ginestra⁴, Maria G Saita⁵, Fabiola Spitaleri⁵, Salvatore Patanè⁶, Antonia Nostro⁴, Valeria Pittalà⁷, Antonino Mazzaglia⁸

¹National Research Council, Institute of Nanostructured Materials (CNR-ISMN) URT of Messina at Dept. of Chemical, Biological, Pharmaceutical and Environmental Sciences (ChiBioFarAm), University of Messina, Viale Ferdinando Stagno d'Alcontres, 31 98166 Messina, Italy; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences (ChiBioFarAm), University of Messina, Viale Ferdinando Stagno d'Alcontres, 31 98166 Messina, Italy.

²Department of Drug and Health Science, University of Catania, Viale Andrea Doria 6 95125 Catania, Italy.

³National Research Council, Institute of Nanostructured Materials (CNR-ISMN) URT of Messina at Dept. of Chemical, Biological, Pharmaceutical and Environmental Sciences (ChiBioFarAm), University of Messina, Viale Ferdinando Stagno d'Alcontres, 31 98166 Messina, Italy.

⁴Department of Chemical, Biological, Pharmaceutical and Environmental Sciences (ChiBioFarAm), University of Messina, Viale Ferdinando Stagno d'Alcontres, 31 98166 Messina, Italy.

⁵Medivis, Via Carnazza 34/C 95030 Tremestieri Etneo, Italy.

⁶Department of Mathematical and Computer Sciences, Physical Sciences and Earth Sciences (MIFT), University of Messina, Viale Ferdinando Stagno d'Alcontres, 31 98166 Messina, Italy.

⁷Department of Drug and Health Science, University of Catania, Viale Andrea Doria 6 95125 Catania, Italy. Electronic address: valeria.pittala@unict.it.

⁸National Research Council, Institute of Nanostructured Materials (CNR-ISMN) URT of Messina at Dept. of Chemical, Biological, Pharmaceutical and Environmental Sciences (ChiBioFarAm), University of Messina, Viale Ferdinando Stagno d'Alcontres, 31 98166 Messina, Italy. Electronic address: antonino.mazzaglia@cnr.it.

PubMed DOI

Abstract

The Periprosthetic Joint Infection (PJI) is one of the most important complications of the joint arthroplasty. This surgical procedure is rising worldwide and is further affecting the public health because of the widespread resistance to antibiotics. New therapeutic strategies and innovative antimicrobial biomaterials development are needed to eradicate pathogens without inducing resistance and ac…

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