Peer-Reviewed Publication
BMC Med Imaging2025;25(1):33.January 30, 2025Journal Article
Distinct Circle of Willis anatomical configurations in healthy preterm born adults: a 3D time-of-flight magnetic resonance angiography study.
Julien Greggio1, Christina Malamateniou1,2, Kelly Pegoretti Baruteau3,4, Constantino Carlos Reyes-Aldasoro5,6, Odaro J Huckstep7, Jane M Francis8, Wilby Williamson9, Paul Leeson10, Adam J Lewandowski11, Winok Lapidaire12
1Department of Midwifery & Radiography, City St George's, School of Health & Psychological Sciences, University of London, Clerkenwell Campus, London, EC1V 0HB, UK.
2Department of Neuroimaging, Kings' College London, London, SE5 8AF, UK.
3Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, WC1N 3BG, UK.
4Elizabeth Garrett Anderson, Institute for Women's Health, University College London, London, UK.
5Department of Computer Science, City St George's, School of Health & Medical Sciences, University of London, London, EC1V 0HB, UK.
6Integrated Pathology Unit, Division of Molecular Pathology, The Institute of Cancer Research, Sutton, UK.
7Department of Biology, United States Air Force Academy, Colorado Springs, CO, USA.
8MyCardium AI, Liverpool, UK.
9School of Medicine, Trinity College Dublin, Dublin, Ireland.
10Oxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, Level 1, Oxford Heart Centre, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.
11Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
12Oxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, Level 1, Oxford Heart Centre, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK. winok.lapidaire@cardiov.ox.ac.uk.
Abstract
BACKGROUND: Preterm birth (< 37 weeks' gestation) alters cerebrovascular development due to the premature transition from a foetal to postnatal circulatory system, with potential implications for future cerebrovascular health. This study aims to explore potential differences in the Circle of Willis (CoW), a key arterial ring that perfuses the brain, of healthy adults born preterm.
METHODS: A tota…
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