Development of highly sensitive lateral flow immunoassay using PdNPs for detection of Plasmodium species.

Kashyap Pandya¹, Preeti Sharma², Maulik Rachh³, Jayendra Patel³

¹Veer Narmad South Gujarat University, Udhana - Magdalla Road, Surat 395007 Gujarat, India; ARKRAY Healthcare Pvt. Ltd., Plot No. 336, 338, 340, Rd Number 3, GIDC, Sachin, 394230 Surat, Gujarat, India. Electronic address: pandyak007@gmail.com.

²Veer Narmad South Gujarat University, Udhana - Magdalla Road, Surat 395007 Gujarat, India. Electronic address: preetisharma@vnsgu.ac.in.

³ARKRAY Healthcare Pvt. Ltd., Plot No. 336, 338, 340, Rd Number 3, GIDC, Sachin, 394230 Surat, Gujarat, India.

PubMed DOI

Abstract

A lateral flow immunoassay (LFIA) employing palladium nanoparticles (PdNPs) labelled with antibodies has been innovatively designed for the precise detection of Plasmodium falciparum pLDH and HRPII antigen. This study focuses on development of LFIA based on PdNPs detection system to substantially enhance the visual detectability (vLOD), achieving an impressive 12 parasites/microliter (p/µl) vLOD i…

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