Peer-Reviewed Publication
NPJ Precis Oncol2025;9(1):16.January 14, 2025Journal Article
Genomic landscape and comparative analysis of tissue and liquid-based NGS in Taiwanese anaplastic thyroid carcinoma.
Chun-Nan Yeh1,2, Shu-Fu Lin2,3, Chia-Ling Wu4, Miaw-Jene Liou2,5, I-Wen Chen2,5, Chiao-Ping Chen2,6, Ching-Fu Chang2,6, Qi-An Wang2, Chiao-En Wu7,8
1Department of Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan, ROC.
2College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.
3Department of Internal Medicine, New Taipei Municipal TuCheng Hospital, New Taipei City, Taiwan, ROC.
4ACT Genomics Co. Ltd., Taipei, Taiwan, ROC.
5Division of Endocrinology and Metabolism, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan, ROC.
6Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan, ROC.
7College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC. jiaoen@gmail.com.
8Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan, ROC. jiaoen@gmail.com.
Abstract
Anaplastic thyroid carcinoma (ATC) is an aggressive cancer that requirements rapid diagnosis and multimodal treatment. Next-generation sequencing (NGS) aids in personalized therapies and improved trial enrollment. The role of liquid-based NGS in ATC remains unclear. This study analyzed ATC samples using tissue-based NGS, liquid-based NGS, or both platforms. Genetic alterations showed highly hetero…
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