Peer-Reviewed Publication
Vet Anim Sci2025;27100414.March 1, 2025Journal Article
Development of a sensitive disease-screening model using comprehensive circulating microRNA profiles in dogs: A pilot study.
Kohei Omura1, Kaori Ide2, Masashi Takahashi3, Yu Furusawa3, Masanori Kobayashi4, Yuichi Miyagawa5, Aki Fujiwara-Igarashi6, Takahiro Teshima7, Yoshiaki Kubo8, Akiko Yasuda8, Karin Yoshida8, Noriyuki Hayakawa8, Masato Kobayashi4, Yasuyuki Momoi9
1Scientific activity support team, ARKRAY Marketing Inc., Yousuien-nai, 59 Gansuin-cho, Kamigyo-ku, Kyoto 602-0008, Japan.
2Tokyo University of Agriculture and Technology, Department of Veterinary Medicine, Laboratory of Veterinary Internal Medicine, 3-5-8 Saiwaicho, Fuchu City, Tokyo, Japan.
3Joint Faculty of Veterinary Medicine, Kagoshima University Veterinary Teaching Hospital, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan.
4Laboratory of Reproduction, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo, 180-8602, Japan.
5Laboratory of Veterinary Internal Medicine II, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan.
6Laboratory of Veterinary Radiology, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino-shi, Tokyo 180-8602, Japan.
7Laboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan.
8Veterinary Medical Teaching Hospital, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino-shi, Tokyo 180-8602, Japan.
9Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan.
Abstract
In the veterinary field, the utility of disease-identification models that use comprehensive circulating microRNA (miRNA) profiles produced through measurements based on next-generation sequencing (NGS) remains unproven. To integrate NGS technology with automated machine learning (autoML) to create a comprehensive circulating miRNA profile and to assess the clinical utility of a disease-screening…
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