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Peer-Reviewed Publication
Redox Biol2025;79103444.February 1, 2025Journal Article

Modulation of iron metabolism by new chemicals interacting with the iron regulatory system.

Yoshiaki Tsuji1, Jun Ninomiya-Tsuji2, Maurice Y F Shen3, Benjamin R DiFrancesco3
1Department of Biological Sciences, Toxicology Program, North Carolina State University, Campus Box 7633, Raleigh, NC, 27695-7633, USA. Electronic address: ytsuji@ncsu.edu.
2Department of Biological Sciences, Toxicology Program, North Carolina State University, Campus Box 7633, Raleigh, NC, 27695-7633, USA.
3Cyclica Inc., 207 Queens Quay W Suite 420, Toronto, ON, M5J 1A7, Canada.
PubMed PMC DOI PDF

Abstract

Despite the vital role of iron and vulnerability of iron metabolism in disease states, it remains largely unknown whether chemicals interacting with cellular proteins are responsible for perturbation of iron metabolism. We previously demonstrated that cisplatin was an inhibitor of the iron regulatory system by blocking IRP2 (iron regulatory protein 2) binding to an iron-responsive element (IRE) lo…

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