Investigation of hydrogen peroxide yields and oxygen consumption in high dose rate irradiation: a TOPAS-nBio Monte Carlo study.

Wook-Geun Shin¹, J Naoki D-Kondo², José Ramos-Méndez², Jay A LaVerne³, Bethany Rothwell¹, Alejandro Bertolet¹, Aimee McNamara⁴, Bruce Faddegon², Harald Paganetti¹, Jan Schuemann¹

¹Physics Division, Department of Radiation Oncology, Massachusetts General Hospital & Harvard Medical School, Boston, MA 02114, United States of America.

²Department of Radiation Oncology, University of California San Francisco Comprehensive Cancer Center, San Francisco, CA 94115, United States of America.

³Radiation Laboratory and Department of Physics and Astronomy, University of Notre Dame, Notre Dame, IN 46556, United States of America.

⁴Radformation Inc, 261 Madison Ave, 9th Floor, New York, NY 10017, United States of America.

PubMed PMC DOI PDF

Abstract

Objective.TOPAS-nBio enables users to simulate dose rate-dependent radiation chemical yields in water radiolysis accounting for inter-track and long-term chemistry for pulsed irradiation. This study aims to extend the TOPAS-nBio chemistry for the special case of continuous high-dose rate scenario, where both intertrack and longer time reactions need to be considered, and to quantitatively validate…

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