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Peer-Reviewed Publication
bioRxiv2025May 6, 2025Journal Article

Boltz-1 Democratizing Biomolecular Interaction Modeling.

Jeremy Wohlwend1,2, Gabriele Corso1,2, Saro Passaro1,2, Noah Getz1,2, Mateo Reveiz1,2, Ken Leidal3, Wojtek Swiderski3, Liam Atkinson4, Tally Portnoi1,2, Itamar Chinn1,2, Jacob Silterra1,2, Tommi Jaakkola1,2, Regina Barzilay1,2
1MIT CSAIL.
2MIT Jameel Clinic.
3Genesis Research, a part of Genesis Therapeutics.
4CHARM Therapeutics.
PubMed PMC DOI PDF

Abstract

Understanding biomolecular interactions is fundamental to advancing fields like drug discovery and protein design. In this paper, we introduce Boltz-1, an open-source deep learning model incorporating innovations in model architecture, speed optimization, and data processing achieving Alphafold3-level accuracy in predicting the 3D structures of biomolecular complexes. Boltz-1 demonstrates a perfor…

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