Correlation of retinal fluid and photoreceptor and RPE loss in neovascular AMD by automated quantification, a real-world FRB! analysis.

Virginia Mares^1,2, Gregor S Reiter¹, Markus Gumpinger¹, Oliver Leigang³, Hrvoje Bogunovic¹, Daniel Barthelmes⁴, Marcio B Nehemy², Ursula Schmidt-Erfurth¹

¹Laboratory for Ophthalmic Image Analysis, Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.

²Department of Ophthalmology, Federal University of Minas Gerais, Belo Horizonte, Brazil.

³RetInSight GmbH, Vienna, Austria.

⁴Department of Ophthalmology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

PubMed PMC DOI PDF

Abstract

PURPOSE: To quantify ellipsoid zone (EZ) loss during anti-VEGF therapy for neovascular age-related macular degeneration (nAMD) and correlate these findings with nAMD disease activity using artificial intelligence-based algorithms. METHODS: Spectral domain optical coherence tomography (Spectralis, Heidelberg Engineering) images from nAMD treatment-naïve patients from the Fight Retinal Blindness! (…

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MeSH Terms

Humans0Tomography, Optical Coherence*Subretinal Fluid*Male0Female0Wet Macular Degeneration*Aged0Retinal Pigment Epithelium*Follow-Up Studies0Visual Acuity*Angiogenesis Inhibitors0Fluorescein Angiography0Photoreceptor Cells, Vertebrate*Intravitreal Injections0Aged, 80 and over0Registries0Retrospective Studies0Middle Aged0Fundus Oculi0Algorithms0

Keywords

anti‐VEGFartificial intelligencegeographic atrophyimage analysismachine learningneovascular AMDoptical coherence tomographyphotoreceptorretina

Article Info

PMID: 39540601
PMCID: PMC11986395
DOI: 10.1111/aos.16799
Received: March 26, 2024
Accepted: November 3, 2024

How to Cite

Mares V et al. Correlation of retinal fluid and photoreceptor and RPE loss in neovascular AMD by automated quantification, a real-world FRB! analysis. Acta Ophthalmol2025;103(3):295-303. doi:10.1111/aos.16799

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