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Peer-Reviewed Publication
Clin Res Cardiol2026;115(3):435-448.March 1, 2026Journal Article

Association of daily physical activity with pulmonary artery pressure in HFpEF and HFmrEF NYHA class III patients: a pilot trial-feasibility and first results.

Ester J Herrmann1, Denise Lange2, Jennifer Hannig3, Gina Zimmer1, Dimitri Gruen4, Till Keller4,5, Albin Edegran6, Linda S Johnson7, Samuel Sossalla1,4,5, Michael Guckert2,3, Birgit Assmus8,9,10
1Department of Medicine I, Cardiology and Angiology, University Hospital Giessen and Marburg, Justus Liebig University, Klinikstr. 33, 35392, Giessen, Germany.
2Institute of Mathematics, Natural Sciences and Data Processing, Technische Hochschule Mittelhessen, University of Applied Sciences, 61169, Friedberg, Germany.
3Cognitive Information Systems Group, Kompetenzzentrum Für Informationstechnologie (KITE), Technische Hochschule Mittelhessen, University of Applied Sciences, 61169, Friedberg, Germany.
4Justus-Liebig-University, 35392, Giessen, Germany.
5German Center for Cardiovascular Research (DZHK), Partner Site Rhein, Main, Germany.
6MEDICALgorithmics, Warsaw, Poland.
7Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.
8Department of Medicine I, Cardiology and Angiology, University Hospital Giessen and Marburg, Justus Liebig University, Klinikstr. 33, 35392, Giessen, Germany. birgit.assmus@innere.med.uni-giessen.de.
9German Center for Cardiovascular Research (DZHK), Partner Site Rhein, Main, Germany. birgit.assmus@innere.med.uni-giessen.de.
10Justus-Liebig-University, 35392, Giessen, Germany. birgit.assmus@innere.med.uni-giessen.de.

Abstract

INTRODUCTION: Supervised physical exercise has been shown to benefit patients with heart failure with preserved/mildly reduced ejection fraction (HFpEF/HfmrEF) by improving symptoms and diastolic function. This study aimed to investigate the correlation between unsupervised daily physical activity and changes in daily pulmonary artery pressure (PAP) in patients with stable NYHA class III heart fai…

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