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Peer-Reviewed Publication
Int J Mol Sci2024;25(19)October 9, 2024Journal Article

Chemokine Receptor N-Terminus Charge Dictates Reliance on Post-Translational Modifications for Effective Ligand Capture and Following Boosting by Defense Peptides.

Ting Xu1, Anne Sophie Schou1, Jarkko J Lackman2, Marina Barrio-Calvo1,3, Lisa Verhallen1,4, Christoffer Knak Goth1,5, Benjamin Anderschou Holbech Jensen1, Christopher T Veldkamp6, Brian F Volkman7, Francis C Peterson7, Gertrud Malene Hjortø1
1Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
2Copenhagen Center for Glycomics, University of Copenhagen, 2200 Copenhagen, Denmark.
3Evaxion Biotech, 2970 Hørsholm, Denmark.
4Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.
5Glx Analytix APS, 2400 Copenhagen, Denmark.
6Department of Chemistry, University of Wisconsin-Whitewater, Whitewater, WI 53190, USA.
7Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
PubMed PMC DOI PDF

Abstract

The chemokine receptors CCR1 and CCR5 display overlapping expression patterns and ligand dependency. Here we find that ligand activation of CCR5, not CCR1, is dependent on N-terminal receptor O-glycosylation. Release from O-glycosylation dependency is obtained by increasing CCR5 N-terminus acidity to the level of CCR1. Ligand activation of CCR5, not CCR1, drastically improves in the absence of gly…

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