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Mol Psychiatry2025;30(4):1461-1465.April 1, 2025Journal Article

Heparin treatment is associated with a delayed diagnosis of Alzheimer's dementia in electronic health records from two large United States health systems.

Benjamin Readhead1, Eyal Klang2,3, Undina Gisladottir4, Maxence Vandromme2, Li Li5, Yakeel T Quiroz6, Joseph F Arboleda-Velasquez7, Joel T Dudley8,2, Nicholas P Tatonetti4,9,10, Benjamin S Glicksberg2, Eric M Reiman8,11
1ASU-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ, 85281, USA. ben.readhead@asu.edu.
2Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
3Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel.
4Department of Biomedical Informatics, Columbia University, New York, NY, USA.
5Sema4, Stamford, CT, USA.
6Departments of Psychiatry and Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
7Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
8ASU-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ, 85281, USA.
9Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
10Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
11Banner Alzheimer's Institute, Phoenix, AZ, 85006, USA.
PubMed PMC DOI PDF

Abstract

Recent studies suggest that heparan sulfate proteoglycans (HSPG) contribute to the predisposition to, protection from, and potential treatment and prevention of Alzheimer's disease (AD). Here, we used electronic health records (EHR) from two different health systems to examine whether heparin therapy was associated with a delayed diagnosis of AD dementia. Longitudinal EHR data from 15,183 patients…

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