Linking clinical trial participants to their U.S. real-world data through tokenization: A practical guide.

Michael J Eckrote¹, Carrie M Nielson², Mike Lu², Tyler Alexander³, Rikisha Shah Gupta², Kim Wah Low², Zhiwei Zhang², Austin Eliazar¹, Reyna Klesh¹, Andrew Kress¹, Matt Bryant², Alex Asiimwe², Nicolle M Gatto^4,5, Nancy A Dreyer⁶

¹HealthVerity, Philadelphia, PA, USA.

²Gilead Sciences, Foster City, CA, USA.

³SimulStat Incorporated, Solana Beach, CA, USA.

⁴Scientific Research & Strategy, Aetion Inc., New York, NY, USA.

⁵Columbia Mailman School of Public Health, New York, NY, USA.

⁶Dreyer Strategies LLC, Newton, MA, USA.

PubMed PMC DOI PDF

Abstract

In drug development, the use of real-world data (RWD) has augmented our understanding of patients' health care experiences and the effects of treatments beyond clinical trials. Although electronic health record (EHR) data integration at clinical trial sites is a widely adopted practice, primarily for recruitment and data capture, a challenge to data utility is the fragmentation of health data acro…

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