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Peer-Reviewed Publication
Clin Pharmacol Ther2025;117(4):1012-1016.April 1, 2025Journal Article

Concomitant Use of Oral Anticoagulants With Oral Dipeptidyl Peptidase-4 Inhibitors and Serious Bleeding Events.

Thanh Phuong Pham Nguyen1,2,3,4, Charles E Leonard1,2,3,5, Colleen M Brensinger1,2,3, Warren B Bilker1,2,3,6, Sophie P Chung7, John R Horn8, Kacie Bogar1,2,3, Todd A Miano1,2,3, Sean Hennessy1,2,3,5
1Center for Real-World Effectiveness and Safety of Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
2Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
3Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
4Translational Center of Excellence for Neuroepidemiology and Neurology Outcomes Research, Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
5Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
6Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
7AthenaHealth, Inc., Watertown, Massachusetts, USA.
8Department of Pharmacy, University of Washington School of Pharmacy, Seattle, Washington, USA.
PubMed PMC DOI PDF

Abstract

In a prior screening study, saxagliptin, a dipeptidyl peptidase-4 inhibitor (DPP-4i), was found to have an increased rate of serious bleeding when used concomitantly with several oral anticoagulants (OACs). We aimed to confirm or refute the associations between concomitant use of individual OACs and DPP-4is and serious bleeding in a large US database, using self-controlled case series (SCCS) and c…

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