A best practices framework for spatial biology studies in drug discovery and development: enabling successful cohort studies using digital spatial profiling.

David Krull¹, Premi Haynes², Anil Kesarwani¹, Julien Tessier³, Benjamin J Chen⁴, Kelly Hunter⁵, Deniliz Rodriguez⁶, Yan Liang⁷, Jim Mansfield⁸, Maxine McClain⁷, Corinne Ramos⁹, Edward Bonnevie², Esperanza Anguiano⁷

¹Precision Medicine, GlaxoSmithKline, Collegeville, USA.

²Cancer Immunology & Cell Therapy Thematic Research Center, Bristol Myers Squibb, Seattle, WA, USA.

³Precision Medicine and Computational Biology, Sanofi, Cambridge, USA.

⁴Translational Medicine, Bristol Myers Squibb, Cambridge, MA, USA.

⁵Molecular Pathology and Histology, ProPath-UK Ltd, Hereford, UK.

⁶Precision Medicine, Bristol Myers Squibb, Lawrenceville, USA.

⁷Spatial Platforms Product Development and Support, NanoString Technologies Inc, Seattle, USA.

⁸Research Business Development, Visiopharm Corp, Broomfield, USA.

⁹Research and Development, Aliri, Loos, France.

PubMed DOI

Abstract

The discovery of biomarkers, essential for successful drug development, is often hindered by the limited availability of tissue samples, typically obtained through core needle biopsies. Standard 'omics platforms can consume significant amounts of tissue, forcing scientist to trade off spatial context for high-plex assays, such as genome-wide assays. While bulk gene expression approaches and standa…

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