Hub disruption in HIV disease and cocaine use: A connectomics analysis of brain function.

Kareem Al-Khalil¹, Ryan P Bell², Sheri L Towe³, Jessica R Cohen⁴, Syam Gadde⁵, James Mu⁶, Shana A Hall⁷, Christina S Meade⁸

¹Duke University School of Medicine, Department of Psychiatry and Behavioral Sciences, 2400 Pratt Street, Durham, NC 27705, USA. Electronic address: kalkhal@gmail.com.

²Duke University School of Medicine, Department of Psychiatry and Behavioral Sciences, 2400 Pratt Street, Durham, NC 27705, USA; Wake Forest University, School of Medicine, 475 Vine Street, Winston-Salem, NC 27101, USA. Electronic address: rpbell@wakehealth.edu.

³Duke University School of Medicine, Department of Psychiatry and Behavioral Sciences, 2400 Pratt Street, Durham, NC 27705, USA; Wake Forest University, School of Medicine, 475 Vine Street, Winston-Salem, NC 27101, USA. Electronic address: stowe@wakehealth.edu.

⁴University of North Carolina at Chapel Hill, Department of Psychology and Neuroscience, 100 E. Franklin Street Suite 200, Chapel Hill, NC 27599, USA. Electronic address: jrcohen@unc.edu.

⁵Duke University Medical Center, Brain Imaging Analysis Center, 40 Duke Medicine Cir #414, Durham, NC 27710, USA. Electronic address: syam.gadde@duke.edu.

⁶Duke University School of Medicine, Department of Psychiatry and Behavioral Sciences, 2400 Pratt Street, Durham, NC 27705, USA. Electronic address: james.mu@duke.edu.

⁷Duke University School of Medicine, Department of Psychiatry and Behavioral Sciences, 2400 Pratt Street, Durham, NC 27705, USA. Electronic address: shana@limbix.com.

⁸Duke University School of Medicine, Department of Psychiatry and Behavioral Sciences, 2400 Pratt Street, Durham, NC 27705, USA; Duke University Medical Center, Brain Imaging Analysis Center, 40 Duke Medicine Cir #414, Durham, NC 27710, USA; Wake Forest University, School of Medicine, 475 Vine Street, Winston-Salem, NC 27101, USA. Electronic address: cmeade@wakehealth.edu.

PubMed PMC DOI PDF

Abstract

BACKGROUND: Cocaine use (CU) is prevalent in people with HIV (PWH). Both conditions are linked to changes in cognitive functioning and neural network topology. The current study utilizes graph theory to investigate functional connectomics associated with HIV and CU, focusing on disruption of densely connected nodes called hubs. METHODS: Resting state functional magnetic resonance imaging (fMRI) f…

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