Heart failure related fatigue: An exploratory analysis of serum osmolality from the national health and nutrition examination survey.

Christine R Hoch¹, N Jennifer Klinedinst², Karen Larimer³, Stephen S Gottlieb⁴

¹Assistant Professor, University of Delaware, School of Nursing, United States. Electronic address: choch@udel.edu.

²Associate Professor, Department of Organizational Systems and Adult Health, University of Maryland, School of Nursing, United States. Electronic address: klinedinst@umaryland.edu.

³Director of Clinical Operations Cardiosense, United States. Electronic address: karen@cardiosense.com.

⁴Professor of Medicine, University of Maryland, School of Medicine, United States. Electronic address: sgottlie@som.umaryland.edu.

PubMed DOI

Abstract

BACKGROUND: Fatigue is a prominent symptom of heart failure (HF). However, underlying mechanisms remain poorly understood. Fluid volume status has been suggested as a physiologic mechanism of HF-related fatigue. Serum osmolality may fluctuate with changes in volume status associated with neurohormonal dysregulation. The relationship of fatigue to serum osmolality has not been assessed in adults wi…

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