CT strain metrics allow for earlier diagnosis of bronchiolitis obliterans syndrome after hematopoietic cell transplant.

Husham Sharifi¹, Christopher D Bertini², Mansour Alkhunaizi¹, Maria Hernandez³, Zayan Musa¹, Carlos Borges¹, Ihsan Turk¹, Lara Bashoura⁴, Burton F Dickey⁴, Guang-Shing Cheng⁵, Gregory Yanik⁶, Craig J Galban⁷, Huawei Henry Guo⁸, Myrna C B Godoy⁴, Joseph M Reinhardt⁹, Eric A Hoffman⁹, Mario Castro¹⁰, Gabriela Rondon⁴, Amin M Alousi⁴, Richard E Champlin⁴, Elizabeth J Shpall⁴, Ying Lu¹¹, Samuel Peterson¹², Keshav Datta⁸, Mark R Nicolls¹, Joe Hsu¹, Ajay Sheshadri²

¹Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA.

²Division of Pulmonary and Critical Care Medicine, University of Texas Health Science Center, Houston, TX.

³Division of Hospital Medicine, Northwestern University, Chicago, IL.

⁴Department of Pulmonary Medicine, MD Anderson Cancer Center, Houston, TX.

⁵Division of Pulmonary, Critical Care and Sleep Medicine, Fred Hutchinson Cancer Center, Seattle, WA.

⁶Blood and Marrow Transplant Division, University of Michigan Health, Ann Arbor, MI.

⁷Department of Radiology, Blood and Marrow Transplant Division, University of Michigan Health, Ann Arbor, MI.

⁸Department of Radiology, Stanford University School of Medicine, Stanford, CA.

⁹Department of Radiology, University of Iowa, Iowa City, IA.

¹⁰Division of Pulmonary, Critical Care and Sleep Medicine, Kansas University Medical Center, Kansas City, KS.

¹¹Department of Biomedical Data Sciences, Stanford University, Stanford, CA.

¹²VIDA Diagnostics, Inc, Coralville, IA.

PubMed PMC DOI PDF

Abstract

Bronchiolitis obliterans syndrome (BOS) after hematopoietic cell transplantation (HCT) is associated with substantial morbidity and mortality. Quantitative computed tomography (qCT) can help diagnose advanced BOS meeting National Institutes of Health (NIH) criteria (NIH-BOS) but has not been used to diagnose early, often asymptomatic BOS (early BOS), limiting the potential for early intervention a…

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Mentioned Companies

VIDA Diagnostics
affiliation

NIH Funding

Grant #11171594
Parametric Response Mapping (PRM) for the detection of chronic lung injury in hematopoietic cell transplant recipients
UNIVERSITY OF MICHIGAN AT ANN ARBOR
$741,498 (FY2025)

Other Funding

NHLBI NIH HHS(R01 HL162661)
United States
NIEHS NIH HHS(P30 ES005605)
United States
NIAID NIH HHS(K23 AI117024)
United States
NHLBI NIH HHS(R01 HL157414)
United States
NCI NIH HHS(P30 CA015704)
United States
NHLBI NIH HHS(R01 HL161037)
United States
NHLBI NIH HHS(U01 HL163124)
United States

MeSH Terms

Bronchiolitis Obliterans*Humans0Hematopoietic Stem Cell Transplantation*Male0Female0Middle Aged0Tomography, X-Ray Computed*Adult0Respiratory Function Tests0Early Diagnosis0Aged0Bronchiolitis Obliterans Syndrome0

Article Info

PMID: 39163616
PMCID: PMC11470239
DOI: 10.1182/bloodadvances.2024013748
Received: May 23, 2024
Accepted: July 29, 2024

How to Cite

Sharifi H et al. CT strain metrics allow for earlier diagnosis of bronchiolitis obliterans syndrome after hematopoietic cell transplant. Blood Adv2024;8(19):5156-5165. doi:10.1182/bloodadvances.2024013748

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