A human brain atlas of χ-separation for normative iron and myelin distributions.

Kyeongseon Min¹, Beomseok Sohn², Woo Jung Kim^3,4, Chae Jung Park⁵, Soohwa Song⁶, Dong Hoon Shin⁶, Kyung Won Chang⁷, Na-Young Shin⁸, Minjun Kim¹, Hyeong-Geol Shin^9,10, Phil Hyu Lee¹¹, Jongho Lee¹

¹Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea.

²Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

³Institute of Behavioral Sciences in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.

⁴Department of Psychiatry, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Republic of Korea.

⁵Department of Radiology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Republic of Korea.

⁶Heuron Co., Ltd, Republic of Korea.

⁷Department of Neurosurgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

⁸Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

⁹Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

¹⁰F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA.

¹¹Department of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

PubMed DOI

Abstract

Iron and myelin are primary susceptibility sources in the human brain. These substances are essential for a healthy brain, and their abnormalities are often related to various neurological disorders. Recently, an advanced susceptibility mapping technique, which is referred to as χ-separation (pronounced as "chi"-separation), has been proposed, successfully disentangling paramagnetic iron from diam…

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