Clinical utility of diffusion MRI-derived measures of cortical microstructure in a real-world memory clinic setting.

Mario Torso¹, Giorgio Fumagalli², Gerard R Ridgway¹, Valeria Elisa Contarino³, Ian Hardingham¹, Elio Scarpini⁴, Daniela Galimberti^4,5, Steven A Chance¹, Andrea Arighi⁴

¹Oxford Brain Diagnostics Ltd, Oxford, UK.

²Center For Mind/Brain Sciences-CIMeC, University of Trento, Rovereto, Italy.

³Neuroradiology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

⁴Neurodegenerative Disease Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

⁵Dept. of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.

PubMed PMC DOI PDF

Abstract

OBJECTIVE: To investigate cortical microstructural measures from diffusion MRI as "neurodegeneration" markers that could improve prognostic accuracy in mild cognitive impairment (MCI). METHODS: The prognostic power of Amyloid/Tau/Neurodegeneration (ATN) biomarkers to predict progression from MCI to AD or non-AD dementia was investigated. Ninety patients underwent clinical evaluation (follow-up in…

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