Self-consistent signal transduction analysis for modeling context-specific signaling cascades and perturbations.

John Cole¹

¹SimBioSys Inc., Champaign, IL, USA. jac@simbiosys.com.

Abstract

Biological signal transduction networks are central to information processing and regulation of gene expression across all domains of life. Dysregulation is known to cause a wide array of diseases, including cancers. Here I introduce self-consistent signal transduction analysis, which utilizes genome-scale -omics data (specifically transcriptomics and/or proteomics) in order to predict the flow of…

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