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Peer-Reviewed Publication
Front Oncol2024;141371752.January 1, 2024Journal Article

Immunotherapy and radiotherapy for older patients with invasive bladder cancer unfit for surgery or chemotherapy: practical proposal by the international geriatric radiotherapy group.

Nam Phong Nguyen1, Ulf Lennart Karlsson2, Brandi R Page3, Monica-Emilia Chirila4,5, Vincent Vinh-Hung6, Olena Gorobets7, Meritxell Arenas8, Mohammad Mohammadianpanah9, Seyed Alireza Javadinia10, Huan Giap11, Lyndon Kim12, Fabien Dutheil13, Vedang Murthy14, Abba Aji Mallum15, Ghassen Tlili16, Zineb Dahbi17, Gokoulakrichenane Loganadane18, Sergio Calleja Blanco19, Satya Bose1, Elena Natoli20,21, Eric Li22, Alessio G Morganti20,21
1Department of Radiation Oncology, Howard University, Washington, DC, United States.
2Department of Radiation Oncology, International Geriatric Radiotherapy Group, Washington, DC, United States.
3Department of Radiation Oncology, Johns Hopkins University, Baltimore, MD, United States.
4Department of Clinical Development, MVision AI, Helsinki, Finland.
5Department of Radiation Oncology, Amethyst Radiotherapy Centre, Cluj-Napoca, Romania.
6Department of Radiation Oncology, Centre Hospitalier Public du Contentin, Cherbour-en-Contentin, France.
7Department of Oral Surgery, University Hospital of Martinique, Fort-de-France, France.
8Department of Radiation Oncology, Sant Joan de Reus University Hospital, University of Rovira, I Virgili, Tarragona, Spain.
9Colorectal Research Center, Department of Radiation Oncology, Shiraz University of Medical Sciences, Shiraz, Iran.
10Non-Communicable Diseases Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran.
11Department of Radiation Oncology, Medical University of South Carolina, Charleston, SC, United States.
12Division of Neuro-Oncology, Mount Sinai Hospital, New York, NY, United States.
13Department of Radiation Oncology, Clinique Sainte Clotilde, Saint Denis, Reunion, France.
14Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
15Department of Radiation Oncology, University of KwaZulu Natal, Durban, South Africa.
16Department of Urology, University Hospital Center, Sousse, Tunisia.
17Department of Radiation Oncology, Mohammed VI University of Health Sciences, Casablanca, Morocco.
18Department of Radiation Oncology, Institut Curie, Paris, France.
19Department of Oral Maxillofacial Surgery, Howard University, Washington, DC, United States.
20Department of Radiation Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
21Radiation Oncology, DIMEC, Bologna University, Bologna, Italy.
22Department of Pathology, Howard University, Washington, DC, United States.
PubMed PMC DOI PDF

Abstract

The standard of care for non-metastatic muscle invasive bladder cancer is either radical cystectomy or bladder preservation therapy, which consists of maximal transurethral bladder resection of the tumor followed by concurrent chemoradiation with a cisplatin-based regimen. However, for older cancer patients who are too frail for surgical resection or have decreased renal function, radiotherapy alo…

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