Peer-Reviewed Publication
Breast Cancer Res2024;26(1):116.July 15, 2024Journal Article
Associations between quantitative measures of mammographic density and terminal ductal lobular unit involution in Chinese breast cancer patients.
Waruiru Mburu1, Changyuan Guo2, Yuan Tian2, Hela Koka1, Sheng Fu1, Ning Lu2, Erni Li2, Jing Li2, Renata Cora1, Ariane Chan3,4, Jennifer L Guida5, Hyuna Sung6, Gretchen L Gierach1, Mustapha Abubakar1, Kai Yu1, Xiaohong R Yang7
1Division of Cancer Epidemiology and Genetics, DHHS, National Cancer Institute, NIH, 9609 Medical Center Drive, Bethesda, MD, 20892-9761, USA.
2National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
3Volpara Health Technologies Ltd, Wellington, New Zealand.
4Institute of Environmental Science and Research, Porirua, GA, 5022, New Zealand.
5Division of Cancer Control and Population Sciences, DHHS, National Cancer Institute, NIH, 9609 Medical Center Drive, Bethesda, MD, 20892-9761, USA.
6Surveillance and Health Equity Science, American Cancer Society, Atlanta, GA, 30303, USA.
7Division of Cancer Epidemiology and Genetics, DHHS, National Cancer Institute, NIH, 9609 Medical Center Drive, Bethesda, MD, 20892-9761, USA. royang@mail.nih.gov.
Abstract
BACKGROUND: Higher mammographic density (MD), a radiological measure of the proportion of fibroglandular tissue in the breast, and lower terminal duct lobular unit (TDLU) involution, a histological measure of the amount of epithelial tissue in the breast, are independent breast cancer risk factors. Previous studies among predominantly white women have associated reduced TDLU involution with higher…
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