Pan-Cancer, Genome-Scale Metabolic Network Analysis of over 10,000 Patients Elucidates Relationship between Metabolism and Survival.

Jesse Bucksot¹, Katherine Ritchie¹, Matthew Biancalana¹, John A Cole¹, Daniel Cook¹

¹SimBioSys, Inc., 180 N La Salle St., Chicago, IL 60601, USA.

Abstract

Despite the high variability in cancer biology, cancers nevertheless exhibit cohesive hallmarks across multiple cancer types, notably dysregulated metabolism. Metabolism plays a central role in cancer biology, and shifts in metabolic pathways have been linked to tumor aggressiveness and likelihood of response to therapy. We therefore sought to interrogate metabolism across cancer types and underst…

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