Peer-Reviewed Publication
Alzheimers Res Ther2024;16(1):152.July 5, 2024Journal Article
Macro and micro structural preservation of grey matter integrity after 24 weeks of rTMS in Alzheimer's disease patients: a pilot study.
Lucia Mencarelli1, Mario Torso2, Ilaria Borghi1,3, Martina Assogna1, Valentina Pezzopane1,4, Sonia Bonnì1, Francesco Di Lorenzo1, Emiliano Santarnecchi5, Federico Giove6,7, Alessandro Martorana8, Marco Bozzali9, Gerard R Ridgway2, Steven A Chance2, Giacomo Koch10,11,12
1Department of Behavioral and Clinical Neurology, Santa Lucia Foundation IRCCS, Via Ardeatina, 306, Rome, 00179, Italy.
2Oxford Brain Diagnostics Ltd, New Rd, Oxford, OX1 1BY, UK.
3Department of Neuroscience and Rehabilitation, University of Ferrara, Via Luigi Borsari, 46, Ferrara, 44121, Italy.
4Center for Translational Neurophysiology of Speech and Communication, Istituto Italiano di Tecnologia, Via Fossato di Mortara, 19, Ferrara, 44121, Italy.
5Precision Neuroscience and Neuromodulation Program & Network Control Laboratory, Gordon Center for Medical Imaging, Massachusetts General Hospital & Harvard Medical School, 125 Nashua Street, Boston, MA, 02114- 1107, USA.
6Cognitive and Motor Rehabilitation and Neuroimaging Unit, IRCCS Fondazione Santa Lucia, Via Ardeatina 306, Rome, 00179, Italy.
7MARBILab, Museo Storico della Fisica e Centro Studi e Ricerche Enrico Fermi, Via Panisperna 89 A, Rome, 00184, Italy.
8Department of Systems Medicine, Memory Clinic, University of Tor Vergata, Via Montpellier 1, Rome, 00133, Italy.
9Neuroscience Department "Rita Levi Montalcini", University of Turin, Via Cherasco, 15, Turin, 10126, Italy.
10Department of Behavioral and Clinical Neurology, Santa Lucia Foundation IRCCS, Via Ardeatina, 306, Rome, 00179, Italy. g.koch@hsantalucia.it.
11Department of Neuroscience and Rehabilitation, University of Ferrara, Via Luigi Borsari, 46, Ferrara, 44121, Italy. g.koch@hsantalucia.it.
12Center for Translational Neurophysiology of Speech and Communication, Istituto Italiano di Tecnologia, Via Fossato di Mortara, 19, Ferrara, 44121, Italy. g.koch@hsantalucia.it.
Abstract
Alzheimer's Disease (AD) is characterized by structural and functional dysfunction involving the Default Mode Network (DMN), for which the Precuneus (PC) is a key node. We proposed a randomized double-blind pilot study to determine neurobiological changes after 24 weeks of PC-rTMS in patients with mild-to-moderate AD. Sixteen patients were randomly assigned to SHAM or PC-rTMS, and received an inte…
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