Construction of a digital twin of chronic graft vs. host disease patients with standard of care.

Gen Li¹, Yi-Bin Chen², Jonathan Peachey³

¹Phesi, East Lyme, CT, USA. gen.li@phesi.com.

²Hematopoietic Cell Transplant & Cell Therapy Program, Massachusetts General Transplant Center: Bone Marrow Transplant Program, Boston, MA, USA.

³Phesi, East Lyme, CT, USA.

PubMed PMC DOI PDF

Abstract

There is an unmet medical need for new clinical trials to evaluate novel therapies in chronic graft-versus-host disease (cGvHD). Disease rarity, ethical issues regarding placebo arms, time, and cost impede clinical trial conduct. Digital twin (DT) technology enables virtual clinical trial arm construction using historical data, circumventing these obstacles. We evaluated the feasibility of constru…

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