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Peer-Reviewed Publication
Microbiol Res2024;285127750.August 1, 2024Journal Article

Transcriptome dynamics of the BHK21 cell line in response to human coronavirus OC43 infection.

Mianhuan Li1, Yang Yang2, Pusen Wang2, Weitao Que2, Lin Zhong2, Zhao Cai3, Yang Liu4, Liang Yang5, Yingxia Liu6
1School of Medicine, Southern University of Science and Technology, Shenzhen 518055, People's Republic of China; Shenzhen Third People's Hospital, National Clinical Research Centre for Infectious Disease, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518112, People's Republic of China.
2Shenzhen Third People's Hospital, National Clinical Research Centre for Infectious Disease, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518112, People's Republic of China.
3Shenzhen Mindray Bio-Medical Electronics Co.,Ltd, Shenzhen 518057, People's Republic of China.
4Southern University of Science and Technology Hospital, Shenzhen 518055, People's Republic of China.
5School of Medicine, Southern University of Science and Technology, Shenzhen 518055, People's Republic of China; Shenzhen Third People's Hospital, National Clinical Research Centre for Infectious Disease, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518112, People's Republic of China. Electronic address: yangl@sustech.edu.cn.
6Shenzhen Third People's Hospital, National Clinical Research Centre for Infectious Disease, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518112, People's Republic of China. Electronic address: yingxialiu@hotmail.com.
PubMed DOI

Abstract

The progress of viral infection involves numerous transcriptional regulatory events. The identification of the newly synthesized transcripts helps us to understand the replication mechanisms and pathogenesis of the virus. Here, we utilized a time-resolved technique called metabolic RNA labeling approach called thiol(SH)-linked alkylation for the metabolic sequencing of RNA (SLAM-seq) to differenti…

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