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Peer-Reviewed Publication
J Am Med Inform Assoc2024;31(9):1953-1963.September 1, 2024Journal Article

Distilling large language models for matching patients to clinical trials.

Mauro Nievas1, Aditya Basu2, Yanshan Wang3, Hrituraj Singh1
1Triomics Research, Triomics, Inc., San Francisco, CA 94105, United States.
2Triomics Research, Triomics, Inc., Bengaluru, Karnataka 560102, India.
3Department of Health Information Management, University of Pittsburgh, Pittsburgh, PA 15260, United States.

Abstract

OBJECTIVE: The objective of this study is to systematically examine the efficacy of both proprietary (GPT-3.5, GPT-4) and open-source large language models (LLMs) (LLAMA 7B, 13B, 70B) in the context of matching patients to clinical trials in healthcare. MATERIALS AND METHODS: The study employs a multifaceted evaluation framework, incorporating extensive automated and human-centric assessments alo…

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