Chronic Pain Management in a CYP2D6 Poor Metabolizer: A Case Report for Oxycodone.

Deepa Pednekar¹, Joshua Russell¹, Chandni Bardolia¹, David Thacker², Nishita Shah Amin¹

¹1 Office of Translational Research and Residency Programs, Tabula Rasa HealthCare, Moorestown, New Jersey.

²2 Precision Pharmacotherapy Research & Development Institute, Tabula Rasa HealthCare, Orlando, Florida.

Abstract

The objective of this case report is to illustrate pharmacogenomics (PGx)-guided oxycodone treatment, given the conflicting data on the analgesic response from oxycodone in Cytochrome P450 (CYP)2D6 poor metabolizers (PMs). PGx-guided therapy can help improve treatment outcomes. This case report describes a 58-year-old patient who was prescribed oxycodone for chronic pain management. The patient pr…

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