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Peer-Reviewed Publication
Clin Pharmacol Ther2024;116(1):117-127.July 1, 2024Journal Article

Comparative Risk of Injury with Concurrent Use of Opioids and Skeletal Muscle Relaxants.

Cheng Chen1,2, Sean Hennessy1,2,3,4, Colleen M Brensinger1,2, Todd A Miano1,2, Warren B Bilker1,2,5, Sascha Dublin6,7, Sophie P Chung8, John R Horn9, Anika Tiwari10, Charles E Leonard1,2,3
1Center for Real-World Effectiveness and Safety of Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
2Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
3Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
4Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
5Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
6Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.
7Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA.
8AthenaHealth, Inc., Watertown, Massachusetts, USA.
9Department of Pharmacy, School of Pharmacy, University of Washington, Seattle, Washington, USA.
10College of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
PubMed PMC DOI PDF

Abstract

Concurrent use of skeletal muscle relaxants (SMRs) and opioids has been linked to an increased risk of injury. However, it remains unclear whether the injury risks differ by specific SMR when combined with opioids. We conducted nine retrospective cohort studies within a US Medicaid population. Each cohort consisted exclusively of person-time exposed to both an SMR and one of the three most dispens…

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