Online Bayesian optimization of vagus nerve stimulation.

Lorenz Wernisch¹, Tristan Edwards¹, Antonin Berthon¹, Olivier Tessier-Lariviere¹, Elvijs Sarkans¹, Myrta Stoukidi¹, Pascal Fortier-Poisson¹, Max Pinkney¹, Michael Thornton¹, Catherine Hanley¹, Susannah Lee¹, Joel Jennings¹, Ben Appleton¹, Phillip Garsed¹, Bret Patterson¹, Will Buttinger¹, Samuel Gonshaw¹, Matjaž Jakopec¹, Sudhakaran Shunmugam¹, Jorin Mamen¹, Aleksi Tukiainen¹, Guillaume Lajoie², Oliver Armitage¹, Emil Hewage¹

¹BIOS Health Ltd, Cambridge, United Kingdom.

²Université de Montréal and Mila-Quebec AI Institute, Montréal, Canada.

PubMed DOI

Abstract

Objective.In bioelectronic medicine, neuromodulation therapies induce neural signals to the brain or organs, modifying their function. Stimulation devices capable of triggering exogenous neural signals using electrical waveforms require a complex and multi-dimensional parameter space to control such waveforms. Determining the best combination of parameters (waveform optimization or dosing) for tre…

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