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Peer-Reviewed Publication
J Immunol Methods2024;528113654.May 1, 2024Journal Article

High-resolution epitope mapping of commercial antibodies to ANCA antigens by yeast surface display.

John S Poulton1, Sajan Lamba2, Meghan Free3, Gang Xi3, Elizabeth McInnis2, Gabrielle Williams2, Stephan T Kudlacek4, David Thieker5, Brian Kuhlman5, Ronald Falk3
1Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; UNC Kidney Center, Chapel Hill, North Carolina, USA. Electronic address: poultonj@email.unc.edu.
2Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
3Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; UNC Kidney Center, Chapel Hill, North Carolina, USA.
4Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Menten AI, San Francisco, California, USA.
5Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
PubMed PMC DOI PDF

Abstract

Epitope mapping provides critical insight into antibody-antigen interactions. Epitope mapping of autoantibodies from patients with autoimmune diseases can help elucidate disease immunogenesis and guide the development of antigen-specific therapies. Similarly, epitope mapping of commercial antibodies targeting known autoantigens enables the use of those antibodies to test specific hypotheses. Anti-…

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