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Gastroenterology2024;166(5):872-885.e2.May 1, 2024Journal Article

A Randomized Trial of Two Remote Health Care Delivery Models on the Uptake of Genetic Testing and Impact on Patient-Reported Psychological Outcomes in Families With Pancreatic Cancer: The Genetic Education, Risk Assessment, and Testing (GENERATE) Study.

Nicolette J Rodriguez1, C Sloane Furniss2, Matthew B Yurgelun1, Chinedu Ukaegbu2, Pamela E Constantinou3, Ileana Fortes4, Alyson Caruso4, Alison N Schwartz4, Jill E Stopfer4, Meghan Underhill-Blazey5, Barbara Kenner6, Scott H Nelson7, Sydney Okumura8, Alicia Y Zhou8, Tara B Coffin9, Hajime Uno2, Miki Horiguchi2, Allyson J Ocean10, Florencia McAllister3, Andrew M Lowy11, Alison P Klein12, Lisa Madlensky11, Gloria M Petersen13, Judy E Garber1, Scott M Lippman11, Michael G Goggins12, Anirban Maitra3, Sapna Syngal14
1Dana-Farber Cancer Institute, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts; Brigham and Women's Hospital, Boston, Massachusetts.
2Dana-Farber Cancer Institute, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.
3Sheikh Ahmed Center for Pancreatic Cancer Research, University of Texas, MD Anderson Cancer Center, Houston, Texas.
4Dana-Farber Cancer Institute, Boston, Massachusetts.
5University of Rochester, School of Nursing, Rochester, New York.
6Kenner Family Research Fund, New York, New York.
7Pancreatic Cancer Action Network Volunteer, Patient Advocate, and Pancreatic Cancer Survivor.
8Color Genomics, Burlingame, California.
9WIRB-Copernicus Group Institutional Review Board, Puyallup, Washington.
10Weill Cornell Medical Center, New York, New York.
11Moores Cancer Center, UC San Diego, San Diego, California.
12Johns Hopkins University, Sol Goldman Pancreatic Cancer Research Center, Baltimore, Maryland.
13Mayo Clinic Cancer Center, Rochester, Minnesota.
14Dana-Farber Cancer Institute, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts; Brigham and Women's Hospital, Boston, Massachusetts. Electronic address: Sapna_Syngal@dfci.harvard.edu.
PubMed PMC DOI PDF

Abstract

BACKGROUND & AIMS: Genetic testing uptake for cancer susceptibility in family members of patients with cancer is suboptimal. Among relatives of patients with pancreatic ductal adenocarcinoma (PDAC), The GENetic Education, Risk Assessment, and TEsting (GENERATE) study evaluated 2 online genetic education/testing delivery models and their impact on patient-reported psychological outcomes. METHODS:…

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